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Angelica Clark

Understanding Sleep Disruptions: Adrenal Dysfunction and Cortisol Connection

Updated: Jun 22, 2023

Many individuals experience difficulties staying asleep or waking up between 2am and 4am, accompanied by symptoms such as feeling hot, anxious, or having trouble falling back asleep. These disruptions can have a significant impact on overall sleep quality and daily well-being.


Understanding Adrenal Dysfunction and Cortisol:

1. Adrenal Glands and Cortisol:

The adrenal glands produce cortisol, a hormone involved in the body's stress response. Cortisol levels naturally fluctuate throughout the day, with higher levels in the morning to provide energy and lower levels in the evening to facilitate relaxation and sleep.


2. Adrenal Dysfunction and High Cortisol:

Chronic stress, poor lifestyle habits, inadequate sleep, and other factors can contribute to adrenal dysfunction, leading to imbalances in cortisol production. This can result in persistently elevated cortisol levels, which may disrupt the sleep-wake cycle and contribute to sleep disturbances.


Sleep Disruptions and Adrenal Dysfunction:

1. Sleep Maintenance Insomnia:

Individuals with adrenal dysfunction may experience sleep maintenance insomnia, characterized by difficulties staying asleep during the night. Waking up between 2 and 4am could be a result of cortisol levels spiking during this time, leading to increased alertness and anxiety.


2. Nighttime Hot Flashes and Anxiety:

Elevated cortisol levels can also cause symptoms like feeling hot, anxious, or restless during the night. These discomforts can contribute to sleep disruptions and difficulty falling back asleep.


Supplements for Adrenal Support and Sleep:

1. Ashwagandha:

Ashwagandha is an adaptogenic herb that may help modulate stress responses and support adrenal function. It has been associated with improved sleep quality and reduced anxiety.


2. Magnesium:

Magnesium is a mineral that promotes relaxation and may aid in better sleep quality. It can also support adrenal function and help regulate cortisol levels.


3. Rhodiola rosea:

Rhodiola rosea is another adaptogenic herb that may help reduce stress, anxiety, and improve sleep quality. It has been associated with improved mental and physical


4. L-Theanine:

L-theanine is an amino acid found naturally in tea leaves, particularly green tea. It is known for its calming and relaxing effects. L-theanine has been found to promote relaxation, reduce anxiety, and improve sleep quality by increasing alpha brain waves and supporting the production of calming neurotransmitters such as GABA.


5. Lavender:

Lavender is an aromatic herb known for its soothing and calming properties. It has been traditionally used to promote relaxation and improve sleep. Research suggests that lavender can help reduce anxiety, improve sleep quality, and increase sleep efficiency. Lavender can be used in the form of essential oil, as a herbal tea, or inhaled as a scent before bedtime.


6. Phosphatidylserine:

Phosphatidylserine is a phospholipid that plays a crucial role in maintaining healthy cell membranes, including those in the brain. It has been studied for its potential to support cognitive function and manage stress. Phosphatidylserine may help reduce cortisol levels, enhance mood, and improve sleep quality, particularly in individuals experiencing stress-related sleep disturbances.


Remember, supplements should be used as part of a comprehensive approach to managing stress, promoting better sleep hygiene, and addressing any underlying factors contributing to sleep disruptions.


Sleep disruptions experienced between 2 and 4am, along with symptoms of heat, anxiety, or difficulty falling back asleep, may be connected to adrenal dysfunction and high cortisol levels. Incorporating strategies to support adrenal health, such as stress management techniques, lifestyle modifications, and potentially considering certain supplements like these may help promote better sleep quality.


However, it is important to consult with a healthcare professional such as a functional medicine practitioner for personalized advice and to determine the most appropriate approach for your specific situation.


References:

1. Chandrasekhar, K., Kapoor, J., & Anishetty, S. (2012). A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian Journal of Psychological Medicine, 34(3), 255–262.

2. Abbasi, B., Kimiagar, M., Sadeghniiat, K., Shirazi, M. M., Hedayati, M., & Rashidkhani, B. (2012). The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. Journal of Research in Medical Sciences, 17(12), 1161–1169.

3. Darbinyan, V., Kteyan, A., Panossian, A., Gabrielian, E., Wikman, G., & Wagner, H. (2000). Rhodiola rosea in stress-induced fatigue—a double-blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine, 7(5), 365–371.


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